Retrospective Analysis of Risk Factors for Venous Thromboembolism in 283 Patients with Lung Cancer during Systemic Therapy

: 【中文题目：283例系统性治疗的肺癌患者静脉血栓栓塞症的危险因素分析】 【中文摘要：背景与目的 肺癌患者是静脉血栓栓塞症（venous thrombo-embolism, VTE）的高危人群，合并VTE者具有较高的死亡率。本研究旨在明确接受系统性治疗肺癌患者的VTE发生情况及影响因素。方法 回顾性分析2016年1月-2018年12月在北京大学第三医院肿瘤化疗与放射病科接受系统性治疗的283例肺癌患者，卡方检验分析VTE与临床特征间的关系，多因素回归分析影响VTE的高危因素。结果 283例肺癌患者中，VTE发生率为12.01%（34/283）。有下肢静脉曲张组的VTE发生率为50.00%（5/10），显著高于无下肢静脉曲张组的9.89%（27/273）（P=0.001）。远处转移患者的VTE发生率为14.05%（26/185），高于带瘤但无远处转移患者的14.00%（7/50），且高于无瘤患者的2.08%（1/48）（P=0.024）。肿瘤活动组的VTE发生率为16.93%（21/124），显著高于稳定组的8.18%（3/159)（P=0.025）。首次药物治疗前白蛋白 0.3 µg/mL组VTE发生率为17.93%（26/145），显著高于≤0.3 µg/mL组的5.80%（8/138）（P=0.006）。接受PICC的患者上肢静脉血栓的发生率为9.71%（17/175），显著高于未行PICC组的1.85%（2/108）（P=0.010）。肺癌病理类型、白细胞、血红蛋白、血小板计数及是否接受抗血管生成药物治疗等因素与VTE的发生率无关。多因素分析显示下肢静脉曲张、低白蛋白血症、D-二聚体升高是VTE的独立影响因素。结论 有无下肢静脉曲张、血白蛋白和D-二聚体水平或许是预测肺癌患者系统性治疗期间发生VTE更为有效的因子，可进一步建立新的预测模型并进行前瞻性验证。】 【中文关键词：肺肿瘤；静脉血栓栓塞；系统性治疗；下肢静脉曲张；D-二聚体】. METHODS: We retrospectively analyzed the cases of 283 patients with lung cancer who received systemic therapy in the Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, from January 2016 to December 2018. Chi-square test and multivariate analyses were used to assess the correlation between clinical features and VTE. RESULTS: Of the patients we observed, 34 developed VTE, with an incidence of 12.01% (34/283). In patients with lower extremity varicose vein (LVV), there was an increase in the incidence of VTE (50.00% vs 9.89%, P=0.001). The incidence VTE in patients with distant metastasis was higher than that in patients without distant metastasis, and higher than that in patients with tumor-free (14.05% vs 14.00% vs 2.08%, P=0.024). The incidence of VTE in patients with active tumor was also significantly higher than that in patients without it (16.93% vs 8.18%, P=0.025). Patients with hypoalbuminemia (albumin 0.3 µg/mL) developed more VTE than those without did (17.93% vs 5.80%, P=0.006). There were no significant correlations between pathological types, blood cell count before systemic therapy including leukocyte, hemoglobin and platelet, or antiangiogenic drugs and VTE. Multivariate analysis showed that LVV, hypoalbuminemia and elevated level of D-dimer were independent risk factors of VTE. CONCLUSIONS: LVV, serum albumin and D-dimer level may be potential and more effective predictors of VTE in lung cancer patients during systemic therapy. Basing on these factors, new predictive model can be built, and further study to validate its efficacy is required.