КОМБИНИРОВАННАЯ ТЕРАПИЯ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ: В ФОКУСЕ- ФИКСИРОВАННАЯ КОМБИНАЦИЯ БЛОКАТОРА АНГИОТЕНЗИНОВЫХ РЕЦЕПТОРОВ И ДИУРЕТИКА

The study aimed to assess the effectiveness and safety of a fixed-dose combination of an ACE inhibitor (losartan) and a diuretic (hydrochlorothiazide) in patients with arterial hypertension (AH) and high or very high cardiovascular risk. The study included 30 patients with Stage I-III AH (13 men and 17 women; mean age 51,9±1,9 years). For 12 weeks, the participants were administered a combination of losartan (50 mg) and hydrochlorothiazide (12,5 mg; once a day, in the morning). Echocardiography and 24-hour blood pressure monitoring (BPM) were performed. In 2 and 4 weeks, a reduction in office systolic BP (SBP) and office diastolic BP (DBP), respectively, was observed. In 12 weeks, BP reduction was even more pronounced, with a reduction in 24-hour SBP (from 141,9±1,9 to 128,6±0,8 mm Hg; p < 0,05). Therefore, a fixed-dose combination of losartan and hydrochlorothiazide (50 mg + 12,5 mg) demonstrated good antihypertensive and cardioprotective effectiveness.