Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse

The antileptazol effect of CP 1414 S (7-nitro-2-amino-3-phenyl-3H-!,5-benzodiazepine-4-one) a newly developed 1,5 benzodiazepine,lasts longer in mice than in rats. After intraperitoneal injection (10 mg/kg) brain levels of the drug were higher and persisted for longer in the mouse than in the rat. Although it cannot be excluded that possible metabolites of CP 1414 S may contribute to the anticonvulsant effect of CP 1414 S, in both species the protective effect correlates well with the brain concentrations of the drug.