CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria

Hongxia Liu,Qinxia Xu,Wenyan Huang,Qi Zhao,Zhihu Jiang,Xinyu Kuang,Zhiling Li,HuaJun Sun,Xiaoyan Qiu

CYP3A5 and CYP3A7 genetic polymorphisms affect tacrolimus concentration in pediatric patients with nephrotic range proteinuria

2019

Hongxia Liu
Qinxia Xu
Wenyan Huang
Qi Zhao
Zhihu Jiang
Xinyu Kuang
Zhiling Li
HuaJun Sun
Xiaoyan Qiu

Purpose The purpose of this study was to investigate the potential impact of CYP3A4, CYP3A5, and CYP3A7 polymorphisms on the concentration and efficacy of tacrolimus in a cohort of pediatric patients with nephrotic range proteinuria.

Keywords:

Nephrotic range proteinuria
CYP3A5
CYP3A4
Medicine
CYP3A7
Diabetes mellitus
Gastroenterology
Anesthesia
Internal medicine
Cohort
Tacrolimus
potential impact
pharmacology toxicology

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