Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys:

Sven Korte,Jorge Luft,Anne von Keutz,Frank Runge,Lars Mecklenburg,Magdalena Wozniak,Serge Zander,Florian Timo Ludwig,Betina Pajaziti,Annette Romeike,Peter Korytko

Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys:

2020

Sven Korte
Jorge Luft
Anne von Keutz
Frank Runge
Lars Mecklenburg
Magdalena Wozniak
Serge Zander
Florian Timo Ludwig
Betina Pajaziti
Annette Romeike
Peter Korytko

Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross...

Keywords:

Spinal cord necrosis
Anesthesia
Medicine
Bolus (medicine)
Maximum tolerated dose
Intrathecal
antisense oligonucleotides
Oligonucleotide
Spinal cord
Lumbar

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