Solid-phase synthesis of methyl carboxymycobactin T 7 and analogues as potential antimycobacterial agents
2003
Abstract A solid-phase approach for the total synthesis of methyl carboxymycobactins 1a – d , with an on-resin cyclization leading to azopine 5 as the key step, was developed. The iron-affinity of these compounds was assessed by a competitive sulfoxine-binding assay, and antimycobacterial activity was tested against the growth of Mycobacterium avium .
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