Thiazole derivatives as inhibitors fosfodieterasa iv.

Compounds selected from the group consisting of a) 1- [3- (3-cyclopentyloxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- [4-methyl-2- ( 1-oxy-pyridin-2-yl) -thia-zol- 5-yl] -methanone, b) 1- [3- (3-isopropoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin -1-yl] -1- [4-methyl-2- (1-oxy-pyridin-2-yl) -thiazol-5- yl] -methanone, c) 1- [3- (3-ethoxy-4- methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- [4-methyl-2- (1-oxy-pyridin-2-yl) -thiazol-5-yl] -methanone, d) 1- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-pyridin-3-yl-thiazole -5-yl) -methanone, e) 1- [3- (3-isopropoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2 -pyridin-3-yl-thiazol-5-yl) -methanone, f) 1- [3- (3-cyclopentyloxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] - 1- (4-methyl-2-pyridin-3-yl-thiazol-5-yl) -methanone, g) 1- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H pyridazin-1-yl] -1- (4-methyl-2-pyridin-2-yl-thiazol-5-yl) -methanone, h) 1- [3- (3-isopropoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-pyridin-2-yl-thiazol-5- yl) -methanone, i) 1- [3- (3-cyclopentyloxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-pyridin- 2-yl-thiazol-5-yl) -methanone, j) 1- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- ( 4-methyl-2-pyrazin-2-yl-thiazol-5-yl) -methanone, k) 1- [3- (3-isopropoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin 1-yl] -1- (4-methyl-2-pyrazin-2-yl-thiazol-5-yl) -methanone, l) 1- [3- (3-cyclopentyloxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-pyrazin-2-yl-thiazol-5-yl) -methanone, m) 1- [3- (3-ethoxy-4 -methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-thiophen-2-yl-thiazol-5-yl) -methanone, n) 1- [ 3- (3-isopropoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-thiophen-2-yl-thiazol-5-yl) -methanone, o) 1- [3- (3-cyclopentyloxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- (4-methyl-2-thiophen-2- yl-thiazol-5-yl) -methanone, p) 1- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-yl] -1- [4- methyl-2-phenyl-thiazol-5-yl] -methanone, q) 1- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4 H-pyridazin-1-yl] -1- [4-methyl-2- (4-methoxyphenyl) -thiazol-5-yl] -methanone, r) 1- [3- (3-ethoxy-4-methoxyphenyl ) -5, 6-dihydro-4H-pyridazin-1-yl] -1- [4-methyl-2- (4-aminophenyl) -thiazol-5-yl] -methanone, s) nitrile of 2 - [( 4- {5- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-carbonyl] -4-methyl-thiazol-2- yl} -phenyl) -hydrazono ] malonate, t) nitrile of 2 - [(4- {5- [3- (3-ethoxy-4-methoxy-phenyl) -5, 6-dihydro-4H-pyridazin-1-carbonyl] -4- methyl-thiazol-2- yl} -phenyl) -hydrazono] -2- (1H-tetrazol-5-yl) -acetic acid and derivatives, solvates, pharmaceutically stereoisomers, including mixtures thereof in all proportions.