Mammary excretion of cannabidiol in rabbits after intravenous administration

— The present study examined the distribution of cannabidiol into milk after an intravenous bolus injection (3 mg kg−1) to lactating rabbits. Drug concentrations in milk and serum were measured by HPLC. Cannabidiol was excreted into milk rapidly and the drug levels in milk increased over a 4–24-h period following the maternal injection. The mean milk to serum concentration ratio was 25·9, indicating a significant accumulation of the drug in milk.