PROTEIN P53 SEBAGAI FAKTOR RISIKO TERJADINYA KETUBAN PECAH DINI

Premature rupture of fetal membrane (PROM) is a complication in pregnancy that is an important problem in obstetrics. Many teory have been explaining that cause of PROM, but the etiology is still unknown. Premature rupture of fetal membrane might be caused by apoptosis. The mechanism of PROM due to the apoptosis might cause the extracellular matrix degradation. The apoptosis is influenced by the signal from extracellular and intracellular protein. The intracellular factor is p53. This factors will cause a fetal membrane damage which induce increasing of caspase-3, so that the increasing of apoptosis in fetal membrane will cause the PROM. The present study is an observational analysis designed as a case-control study. The study was carried out in Dr. Hasan Sadikin Hospital and Central Laboratorium of Medical School of Padjadjaran University. The case group consist of 81 patients of PROM selected based on appropriate acceptance and rejection criteria taken by consecutive sampling. The control group consist of 81 patients with normal pregnancies at the age of ?37- 9,734 U/ml) than the normal pregnancy with p 0,97 U/ml would increased in the incidence of PROM more than thirty times