コクサキー・ウイルス感染症の病理組織学的研究 (II)

The SARAGAI strain of coxsackie group of viruses was challenged with the suckling mice of age 48 hours to compare the pathogenic pictures with two strains investigated in the preceeding paper.(1) The changes in the pancreas were remarkable. These were characterized by the severe pancreatitis with destructive necrosis of glandular cells after 2 days of inoculation, and occasionally soon after 1 day, which could be considered to be a direct cause of fatal episode.(2) The lung lesion were initiated by the catarrh and subsequently turned into interalveolar pneumonia of minor degree. The liver cell revealed cloudy swelling.No significant changes were observed in the kidney tissues. Nephrotic picture was seen in the several instances after 2 days of inoculation.(3) No extensive muscular involvement illustrated by the necrosis of the fibre and cellular infiltration shown in the previous OKUMOTO and DOHI strain was not observed in this case. Atrophic degeneration of fibre in the striated muscle and the hyaline degeneration of minor degree was the only manifestation.(4) There were mild changes in the central nervous system in a few cases, illustrated by the pycnosis of nucleus and swelling of nerve cells. Generally, no acceptable involvement was obtained in this system.(5) Fat tissue revealed no significant changes except few cases which demonstrated atrophic degenerations and cellular infiltrations.(6) The alternative selection of intraperitoneal route and intracerebral route manifested no significant difference.(7) The systemic changes caused in this strain were of minor degree except of pancreas. The incidence and the type of lesion might be elucidated by the difference of the strains and the age of host.