Effects of High Altitude Exposure on Plasma and Urinary Digoxin-like Immunoreactive Substance

Six young healthy subjects underwent a 20 day exposure to altitude, at 4930 m (16,174 ft), to evaluate possible plasma and urine digoxin-like immunore-active substance (DLIS) changes accompanying the altered water and electrolyte balance induced by hypoxia. We studied DLIS, plasma renin activity (PRA), aldosterone, atrial natriuretis peptide (ANP), and arginine vasopressin (ADH) in serial blood and urine samples