FRI0480 Clinic and Mortality Differences Between Sclerodermic Men and Women of the Rescle Cohort

Background Studies evaluating the difference between men and women diagnosed of scleroderma (SSc) are scarce (1-5) because of the shortage of male patients. Objectives Assessing the existence of differences in clinical presentation and mortality causes among men and women in a large cohort of Spanish patients diagnosed with SSc. Methods A registry of patients with SSc has been performed by the Spanish network for systemic sclerosis (RESCLE) since 2008, in which 90 clinical, immunological and capillaroscopic variables were collected prospectively. Data were collected until May 2014 for this study. Results 1506 patients (1341 women), were included. Overall ratio female/male was 8/1. By subtypes lcSSc and preSSc were more frequent in females [84 (51%) vs 808 (60%), p0.023; 6 (3.6%) vs100 (7.5%), p0.076, respectively] and dcSSc in males [62 (38%) vs 293 (22%), p Conclusions 1. In the RESCLE cohort, smoking and ILD were more frequent in males, and sicca syndrome and ANA positivity in women. 2. ILD was the most common cause of death in men and PAH in women. 3. PAH was more frequently a cause of death in women than in men. 4. Men had less survival since the onset of symptoms. References Simeόn CP et al, Br J Rheumatol 1996. Gaultier JB et al, Rev Med Interne 2008. Panopoulos ST et al, J Rheumatol 2013. Hussein H et al, J Rheumatol 2014. Elhai M et al, Ann Rheum Dis 2014. Disclosure of Interest None declared