Hemophagocytic Syndrome Associated with Herpes Virus 8 and Multicentric Castleman Diseases in A HIV-Negative Patient

The Hemophagocytic syndrome (HS) is a very rare and aggressive disorder characterized by strong immunological activation of the mononuclear phagocyte system sometimes triggered by viral infections such as Epstein-Barr Virus. Castleman disease is a heterogeneous group of lymphoproliferative disorders associated in some cases with the human immunodeficiency virus (HIV) and human Herpes Virus 8 (HHV-8). The association of HHV-8, Multicentric Castleman Disease (MCD) and Hemophagocytic Syndrome is extremely rare. There are very few reported cases in literature, mostly in HIV positive elderly patients with fatal prognosis.We report a case of Hemophagocytic syndrome, HHV-8 and MCD on an HIV negative young adult. J Microbiol Infect Dis 2017; 7(4):202-206