Double carboxylation of o-alkynyl acetophenone with carbon dioxide
2016
A copper-catalyzed double carboxylation of o-alkynyl acetophenone using carbon dioxide to afford 1(3H)-isobenzofuranylidene dicarboxylic esters in good yields is described. The reaction proceeds via a carboxylation/intramolecular cyclization/carboxylation sequence. Alkyl-substituted substrates show much higher double carboxylation product selectivities than aryl-substituted substrates.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
119
References
22
Citations
NaN
KQI