Oxygen management in mechanically ventilated patients: A multicenter prospective observational study

Abstract Purpose To observe arterial oxygen in relation to fraction of inspired oxygen (F I O 2 ) during mechanical ventilation (MV). Materials and methods In this multicenter prospective observational study, we included adult patients required MV for >48 h during the period from March to May 2015. We obtained F I O 2 , PaO 2 and SaO 2 from commencement of MV until the 7th day of MV in the ICU. Results We included 454 patients from 28 ICUs in this study. The median APACHE II score was 22. Median values of F I O 2 , PaO 2 and SaO 2 were 0.40, 96 mm Hg and 98%. After day two, patients spent most of their time with a F I O 2 between 0.3 and 0.49 with median PaO 2 of approximately 90 mm Hg and SaO 2 of 97%. PaO 2 was ≥100 mm Hg during 47.2% of the study period and was ≥130 mm Hg during 18.4% of the study period. F I O 2 was more likely decreased when PaO 2 was ≥130 mm Hg or SaO 2 was ≥99% with a F I O 2 of 0.5 or greater. When F I O 2 was I O 2 was less likely decreased regardless of the value of PaO 2 and SaO 2 . Conclusions In our multicenter prospective study, we found that hyperoxemia was common and that hyperoxemia was not corrected.