AB0331 DEPRESSION AND ANXIETY IN PATIENTS WITH RHEUMATOID ARTHRITIS

2019 
Background Rheumatoid arthritis (RA) is a chronic inflammatory joint disease leading to substantial morbidity and mortality and had a major economic and psychological impact on individuals with RA and their families. The prevalence of depressive disorder in RA was 17% and associated with poorer outcomes Objectives To evaluate prevalence of depression and anxiety and their related factors in patients with RA. Methods In this cross-sectional study, 464 patients with RA from two RA registries, the Siriraj Rheumatoid Arthritis (SiRA) registry and the Thai Army Rheumatoid Arthritis Cohort (TARAC) were enrolled. Demographic data and clinical variables, including disease activity, functional status, health-related quality of life, and cognitive function, were collected. Depression and anxiety were assessed using the Thai version of the Hospital Anxiety and Depression Scale (Thai HADS). Results Based on the Thai HADS cutoff value of more than 8 out of 21, 12.5% and 14.5% had some degrees of depression and anxiety, respectively. The proportion of depression and anxiety elevated with increasing disease activity or worsening functional status. However, in multivariate analyses, only global health [RR (95%CI) 0.98 (0.96 - 0.99), p 0.001] was negatively associated with depression, after adjusted for covariate. For anxiety, functional disability [RR (95%CI) 2.46 (1.33 - 4.54), p 0.004] and marital status [married: RR (95%CI) 2.43 (1.25 - 4.73), p 0.009] significantly increased the risk, while disease duration 10 years or more [RR (95%CI) 0.45 (0.25 - 0.80), p 0.007] and global health [RR (95%CI) 0.97 (0.95 - 0.98), p Conclusion Depression and anxiety are common in patients with RA. Patients’ perception of their current health is significantly related to mood disorders. Therefore, mental health status, especially mood disturbances, should be addressed in routine practice to improve quality of life in RA. Disclosure of Interests None declared
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