Preparation and biological activity of some 2-substituted 3-(4'carboxyphenyl)-7-nitro-4 (3H)-quinazolinones.
1980
: 2-Methyl-7-nitro-3,1-(4H)-benzoxazin-4-one (4) (1) has been treated with various carboalkoxy anilines to furnish 2-methyl-3-(4'carboalkoxyphenyl)-7-nitro-4 (3H)-quinazolinones (1-3). Condensation of 1-3 with aromatic aldehydes yielded 2-styryl-3-(4'carboalkoxyphenyl)7-nitro-4 (3H)-quinazolinones (4-21 except 6). Comp. 17 was the most active one against B. subtilis and S. aurens.
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KQI