HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/β-Catenin Signaling Pathway.

J Goto,Yoichiro Otaki,Tetsu Watanabe,Yuta Kobayashi,T Aono,Ken Watanabe,Masahiro Wanezaki,Daisuke Kutsuzawa,Shigehiko Kato,Harutoshi Tamura,Satoshi Nishiyama,Takanori Arimoto,Hiroki Takahashi,Tetsuro Shishido,Masafumi Watanabe

HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/β-Catenin Signaling Pathway.

2020

J Goto
Yoichiro Otaki
Tetsu Watanabe
Yuta Kobayashi
T Aono
Ken Watanabe
Masahiro Wanezaki
Daisuke Kutsuzawa
Shigehiko Kato
Harutoshi Tamura
Satoshi Nishiyama
Takanori Arimoto
Hiroki Takahashi
Tetsuro Shishido
Masafumi Watanabe

The HECT (homologous to the E6-AP carboxyl terminus)-type ubiquitin E3 ligase ITCH is an enzyme that plays an important role in ubiquitin-proteasomal protein degradation. Disheveled proteins (Dvl1 ...

Keywords:

Phosphorylation
Homologous chromosome
Ubiquitin
Enzyme
Ubiquitin ligase
Muscle hypertrophy
Chemistry
protein degradation
Beta-catenin
Cell biology

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