Correlation of apparent diffusion coefficient (ADC) value at 3.0 T diffusion-weighted MR with total lesion glycolysis(TLG) on 18F-FDG PET/CT of NSCLC

241 Objectives The purpose of this study was to investigate the potential correlation of the apparent diffusion coefficient derived from 3.0 Tesla(T) diffusion-weighted (DW)-MRI and glucose metabolic tumor burden determined by the total lesion glycolysis (TLG) at 18F-fluorodeoxy-glucose(FDG) positron emission tomography/computed tomography (PET/CT) in non-small cell lung cancer (NSCLC) Methods 3.0 T DW-MRI of thoracic and whole-body 18F-FDG PET/CT in two successive days were performed in 36 NSCLC patients who were proved by fine-needle biopsy or surgery. The apparent diffusion coefficient(ADC) maps were calculated automatically. ADC values of the primary tumors were measured with a volume of interest (VOIs) covering the whole solid part of the tumor. TLG was automatically generated on MIM software using a gradient edge detection method. The Spearman rank correlation test was performed for ADC values and TLG. Results There was no significant correlation between TLG and ADC in whole sample. However, data revealed significant inverse correlation between the ADCmin and TLG(r=-0.697, p=0.006) in squamouscell lung carcinomas (SCLCs) but not in adenocarcinomas. In contrast, ADCmean did not allow for any correlation to TLG either in SCLCs or adenocarcinomas. Conclusions There was significant reverse correlation between ADCmin and TLG in SCLCs, but not in patients of adenocarcinomas.