Chromogranin A - A New Panorama for Chronic Periodontitis and Psychosocial Stress

Aims: The aim of this study is to determine, compare the Cg-A levels in saliva and plasma in periodontal healthy, in patients with periodontal disease and correlate the same with the stress factor.Materials and Methods: The study involved thirty subjects. There were categorized into three groups with Group I (10 subjects with healthy periodontal status), Group II (10 subjects with mild to moderate periodontitis) and Group III (10 subjects with severe periodontitis). The clinical parameters such as plaque index, gingival bleeding index, clinical attachment loss and probing depth were recorded. Stress was measured using Holme and Rahe stress rating scale. Blood and Saliva sample were collected and Serum Plasma and Saliva CgA levels evaluated using ELISA. The data obtained from all the three groups were analyzed using SPSS Systat 12 software. The mean variables between the three groups were analysed using Kruskal Wallis test. The correlation between the variables and the stress scores was assessed by Pearson’s correlation test.Results: The results of the study showed significantly higher CgA levels in saliva and plasma of patients with severe periodontitis compared with moderate periodontitis and healthy individuals (P < 0.05). There was also a positive correlation between stress scores and Salivary, Serum CgA levels and all clinical parameters.Conclusion: A significant association between elevated Cg A levels in saliva and plasma with periodontal disease was present in our study. The results suggest that Salivary and Plasma Cg A can be considered as a useful biomarker for evaluating etiopathogenesis of Periodontitis