1197 Multidisciplinary treatment of Ewing's sarcoma: Results of the CESS 81 and 86 studies

Combined modality treatment has improved the prognosis for Ewing's sarcoma. The impact of surgery ± radiotherapy on prognosis was evalu-ated in 272 protocol patients (pts) treated according to the CESS 81 and 86 studies, 1981–1991. The estimated relapse-free survival at 13 years is 57%. 76 pts (28%) had radiotherapy and 193 (71%) surgery ± radiotherapy. The incidence of local or local/systemic recurrences was 14% for the whole group, 8% with surgery ± radiotherapy and 29% with radiotherapy. The incidence of systemic relapse was 24% for the whole group, 28% with surgery ± radiotherapy, and 14% with radiotherapy. In pts with small tumors ( % after surgery and 21% after radiotherapy. When the resection was radical or wide the local recurrence rate was 5%, compared to 14% with marginal or intralesional resections. It is concluded that surgery adds to the safety of local contrai, but seems to be associated with more systemic disease. With support of Deutsche Krebshilfe and EC BIOMED 1.