Complexation of porphyrins with silver and zeolite nanoparticles

It is known that nanoparticles of colloidal silver and zeolites due to the porosity have an extremely large specific surface, which is an order of magnitude increases their sorption capacity. Previously we synthesized a set of water-soluble cationic porphyrins and metalloporphyrins and in the laboratory in vitro had shown their high effectiveness against the various cancer cell lines, and against a variety of microorganisms. The aim of this work was to study of processes sorption/desorption of porphyrins on nanoparticles of silver and zeolites. The interaction of cationic porphyrins with silver nanoparticles of 20 nm diameter was studied in the visible spectrum, in the range 350-800 nm. Investigation of sorption dynamics of porphyrins in the silver nanoparticles using two porphyrins: a) meso-tetra (4-N-butyl pyridyl) porphyrin (TBut4PyP), b) Ag-TBut4PyP, as well as of photosensitizer Al-phthalocyanine was carried out. Analysis of the dynamics of change in the absorption spectra for porphyrins TBut4PyP, Ag-TBut4PyP, Zn-TBut4PyP and Zn-TOEt4PyP by adding of nanoparticles of colloidal silver and zeolites leads to the conclusions: 1. nanoparticles of colloidal silver and zeolites are promising adsorbents for cationic porphyrins (sorption of 55-60% and 90-95%, respectively); 2. sorbents stable long (at least 24 hours) keeps the cationic porphyrins; 3. on nanoparticles of colloidal silver and zeolites an anionic and neutral porphyrins not be adsorbed or adsorbed bad.