Medicinals with properties of warming Yang and tonifying Qi in terms of Traditional Chinese Medicine: their effects on left ventricular ejection fraction and aldosterone in rats with induced failure heart

Abstract OBJECTIVE To investigate on Left ventricular ejection fraction value and aldosterone of two medicinals of Traditional Chinese Medicine (TCM) with the properties of warming Yang and tonifying Qi in terms of TCM theory. METHODS An animal model of coronary ligation of heart failure after myocardial infarction was employed to study the influence of these two kinds of drugs on three batches of rats. On the basis of the average score of left ventricle ejection fraction during the investigation, there were some different groups, including WenYang (the warming Yang ) group, YiQi (tonifying Qi ) group, WenYang and YiQi group, captopril group, digoxin group. In additional, an artificial operation group was set for comparison. The systemic intervention using these medicinal and drugs was taken effects on the 2nd day after the operation of myocardial infraction (MI) with once a day. At week one, two, and four after the MI treatment, evaluated were EF values, and ferritin, angiotensin-II and aldosterone in the rats’ plasma. RESULTS At week one and week two, the medicinal of WenYang, YiQi, WenYang pluse YiQi, and digoxin could improve left ventricular ejection fraction in rats with heart failure; Compared to the model group, captopril Left ventricular EF value increased, but there was not significant. At week four, heart failure and left ventricular EF values was improved in the intervention group and the other four captopril drug intervention. At week one in the rats with drug intervention, the medicinals of YiQi, WenYang plus YiQi, and captopril could inhibit activation in vivo hormone aldosterone in heart failure rats; aldosterone in WenYang group and digoxin group were not different from that in the model group at week two and four. CONCLUSION Chinese medicinals with properties of WenYang, YiQi have significant effect on improving left ventricular EF in rats with heart failure; compared to YiQi medicinals, WenYang medicinals that inhibit the effectiveness of the time required for the activation of the role of aldosterone. The medicinals of WenYang and YiQi seems better by inhibiting the activation of the hormone aldosterone after failing to inhibit ventricular remodeling to improve heart failure.