Expeditious One‐Pot, Four‐Step Preparation of 2‐t‐Butoxycarbonyl‐6‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline and an Improved Conversion to Its 6‐Cyano Derivative.

David W. Gordon,Carol A. Bains

Expeditious One‐Pot, Four‐Step Preparation of 2‐t‐Butoxycarbonyl‐6‐hydroxy‐1,2,3,4‐tetrahydroisoquinoline and an Improved Conversion to Its 6‐Cyano Derivative.

2010

David W. Gordon
Carol A. Bains

Title compound (IV) is obtained in multigram quantities by a novel sequential one-pot procedure comprising imination/Pictet—Spengler cyclization/demethylation/Boc-protection.

Keywords:

Tetrahydroisoquinoline
Demethylation
Chemistry
Organic chemistry

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