Evidence-based discriminant analysis: A new insight into iron profile for the diagnosis of parkinson's disease

Introduction: Parkinson's disease is the second most common neurodegenerative disorder. Neurochemical studies have implicated metals in pathogenesis of PD. Objectives: To examine the association of serum iron, transferrin, ferritin, transferrin saturation and UIBC in PD patients and to derive the Discrimination Function with scores of these variables to correctly classify PD cases and healthy controls. Methods: In the present study, identification of biomarker pool in case-control study involving 79 PD cases and 80 healthy controls were performed. Results: The results of independent t-test analysis showed that PD cases presented significantly higher (P