Use of Negative-Pressure Wound Therapy on Malignant Wounds

The use of negative-pressure wound therapy (NPWT) is traditionally contraindicated in malignant wounds due to concerns that it may promote tumorigenesis and expedite metastasis. However this belief is largely derived from studies on normal tissue and no literature directly supports the hypothesis that NPWT modulates oncological progression. Several studies reported the use of this technology in malignancy for palliative purposes with satisfactory outcome. Most recently, our own experience demonstrated successful closure of malignant wounds with the assistance of NPWT and no overt tumor progression on follow-up. These cases, as well as others in the literature, demonstrated that use of NPWT should not be considered an absolute contraindication in malignancy. Individualized approaches taking into account the patient’s clinical scenario, the available evidence, as well as the risks and benefits of this technology are recommended.