Миелопероксидаза и лактоферрин в сыворотке крови и ликворе детей, больных менингитом

We measured concentrations of myeloperoxidase (MPO) and lactoferrin (LF) in the serum and the cerebrospinal fluid (CSF) of children with meningitis, both bacterial (BM) and aseptic (AM) as well as with acute viral infections, using enzyme-linked immunosorbent assay. MPO and LF concentrations in the serum of all patient groups were significantly higher than those in healthy blood donors; furthermore MPO concentration in the serum of children with BM was significantly higher than that in children with aseptic meningitis AM. The concentrations of both MPO and LF in CSF were elevated significantly in children with BM compared with patients with AM. MPO and LF levels in the CSF of children with BM ranged from 26 to 3900 ng/mL with a mean of 703 ng/mL (SE ± 240) and from 0 to 22000 ng/mL with a mean of 5384 ng/mL (SE ± 1453), respectively, whereas MPO and LF levels in the CSF of children with AM ranged from 0 to 80 ng/mL with a mean of 16 ng/mL (SE ± 5) and from 0 to 1000 ng/mL with a mean of 138 ng/mL (SE ± 60), respectively. Therefore, based on our findings, we propose the usefulness of measuring myeloperoxidase and lactoferrin as a possible diagnostic tool and therapeutic monitor in the evaluation of children with meningitis. (Med. Immunol., 2002. vol. 4, N 4-5, pp 565-572)