Association Analysis of FOXO3 Longevity Variants with Blood Pressure and Essential Hypertension

Brian J. Morris,Randi Chen,Timothy A. Donlon,Daniel S. Evans,Gregory J. Tranah,Neeta Parimi,Georg Ehret,Christopher Newton-Cheh,Todd B. Seto,D. Craig Willcox,Kamal Masaki,Kei Kamide,Hirochika Ryuno,Ryosuke Oguro,Chikako Nakama,Mai Kabayama,Koichi Yamamoto,Ken Sugimoto,Kazunori Ikebe,Yukie Masui,Yasumichi Arai,Tatsuro Ishizaki,Yasuyuki Gondo,Hiromi Rakugi,Bradley J. Willcox

Association Analysis of FOXO3 Longevity Variants with Blood Pressure and Essential Hypertension

2016

The minor alleles of 3 FOXO3 single nucleotide polymorphisms (SNPs)-rs2802292, rs2253310, and rs2802288-are associated with human longevity. The aim of the present study was to test these SNPs for association with blood pressure (BP) and essential hypertension (EHT).

Keywords:

Longevity
Genetic association
Essential hypertension
Genetics
Single-nucleotide polymorphism
Genotype
Allele
Genome-wide association study
Bioinformatics
Blood pressure
Medicine

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