Design and syntheses of some new diphenylaminoisoxazolines as potent anti-inflammatory agent

In the present investigation, a QSAR study is performed on twenty diphenylamino-2-isoxazoline derivatives using modified version of Allinger MM2 force field in Chem3D ultra structural descriptors. The relationship between anti-inflammatory activity and various descriptors is established by stepwise multiple regression analysis. The analyses have produced well predictive and statistically significant QSAR models which are further cross validated. This study helps to design some expectedly potent compounds and synthesized, accordingly. These compounds are auxiliary screened spectroscopically and tested for anti-inflammatory activity. All compounds have showed better activity when compared with ibuprofen as standard. These compounds are further subjected to ulceration studies showing good results with almost no ulcerogenic activity.