Synthesis of New Thiourea Scaffold Compounds

It is well known that thiourea derivatives exhibit potent antibacterial [1], fungicidal [2], antitubercular [3], antitumor [4], antiviral [5, 6], analgesic [7] bioactivities and are also useful as insecticides [8, 9], fungicides [10], herbicides [11], and plant-growth regulators [12]. The compounds containing thiourea as structural fragment in their molecules are suitable candidates for chemical modeling as precursors in the synthesis of heterocyclic active derivatives. The thioureides compounds are useful ligands in coordination chemistry, being studied their complexation behaviour, general characterization and biological activity, especially as cancerostatic agents [13]. Several works present new thiourea derivatives exhibiting good action against parasites [14, 15]. The search for compounds with anti-parasitic activity is a theme of continuous interest because of the urgent need to treat and control parasitic diseases. In this paper we have been focusing on the preparation and characterization by physical and spectroscopic data of new benzoylthioureas derivatives. These compounds are in course of testing in order to establish their antiparasitic activity.