New Podophyllotoxin Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxicity of 4β-O-Propenylpodophyllotoxin Ethers

Yadagiri Bathini,Andrew Scholte,Sean Kelly,Ronald G. Micetich,Moshen Daneshtalab

New Podophyllotoxin Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxicity of 4β-O-Propenylpodophyllotoxin Ethers

1999

Yadagiri Bathini
Andrew Scholte
Sean Kelly
Ronald G. Micetich
Moshen Daneshtalab

Abstract 4β-0-Propenylethers of podophyllotoxin 3a-e were prepared from 4-chIoro-4-deoxypodophyllotoxin 2 and allylic alcohols. Cytotoxicity of these compounds against KB cells is reported.

Keywords:

Podophyllotoxin
Organic chemistry
Allylic rearrangement
Podophyllotoxin derivatives
Cytotoxicity
Chemistry

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