Differentiating diffuse from focal pattern on Computed Tomography in multiple myeloma: added value of a Radiomics approach

Abstract Purpose Focal pattern in multiple myeloma (MM) seems to be related to poorer survival and differentiation from diffuse to focal pattern on computed tomography (CT) has inter-reader variability. We postulated that a Radiomic approach could help radiologists in differentiating diffuse from focal patterns on CT. Methods We retrospectively reviewed imaging data of 70 patients with MM with CT, PET-CT or MRI available before bone marrow transplant. Two general radiologist evaluated, in consensus, CT images to define a focal (at least one lytic lesion >5 mm in diameter) or a diffuse (lesions Results The pathological group included: 22 diffuse and 39 focal patterns. After feature reduction, 9 features were different (p  Conclusion A Radiomics approach improves radiological evaluation of focal and diffuse pattern of MM on CT.