Aqueous chemistry of the smallest rare earth: Comprehensive characterization of radioactive and non-radioactive scandium complexes for biological applications

The aqueous chemistry of scandium(III) is of emerging interest for biological applications, specifically in nuclear medicine, as radioactive isotopes of scandium are becoming more readily accessible. In contrast to other rare earths, Sc3+ has no d or f electrons, limiting characterization of corresponding coordination complexes to spectroscopic techniques that do not rely on the characteristic electronic transitions of f-elements or transition metal ions. Herein, we provide a comprehensive overview on characterization techniques suitable to elucidate the solution behavior of small and macromolecular complexes of the smallest rare earth.