СРАВНИТЕЛЬНАЯ ОЦЕНКА ПАЦИЕНТОВ С АНКИЛОЗИРУЮЩИМ СПОНДИЛИТОМ И НЕРЕНТГЕНОЛОГИЧЕСКИМ АКСИАЛЬНЫМ СПОНДИЛОАРТРИТОМ

Objective: to study clinical presentations, disease activity, and functional impairments  in patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis  (nr-axSpA). Subjects and methods. A total of 153 patients were examined in the period 2010 to 2013. They were divided into two groups: 1) 119 patients with a valid diagnosis of AS; 2) 34 with nr-axSpA. BASDAI, BASFI, BASMI, MASES, erythrocyte sedimentation rate, and HLA-B27 antigen were determined  in both groups. The mean age of the patients was 36.5±0.7 years and 27.0±1.2 years and the disease duration 14.7±0.6 and 4.1±0.5 years in Groups 1 and 2, respectively. Results and discussion. Among the patients with AS and those with nr-axSpA, men accounted  for 68.9 and 70.6%, respectively. The axial type was predominant in both groups (53.7% in Group 1 and 67.6% in Group 2). The mean visual analogue scale (VAS) pain score was 40.6±1.6 mm in Group 1 and 31.6±2.4 mm in Group 2 (p 4 was not noted in Group 2. Higher BASMI scores were found in the patients with AS (1.9±0.1)  than in those with nr-axSpA (0.5±0.1). Conclusion. The ASAS criteria for axSpA enable one to establish its diagnosis in the early stage until stable functional impairments  emerge. In the pre-radiographic stage, the patients have lower disease activity and pain.