Long term outcomes for patients with von Hippel-Lindau and Pheochromocytoma: defining the role of active surveillance
2020
Abstract Introduction Patients with a confirmed germline mutation in the von Hippel-Lindau (VHL) tumor suppressor gene have been followed at the National Cancer Institute since the 1980s. In this study, we identify VHL patients with pheochromocytoma and long-term follow-up to determine the best candidates for active surveillance and surgical resection. Methods A prospectively collected database of patients with a confirmed germline VHL mutation was reviewed to identify patients with a history of pheochromocytoma and at least 10 years of follow up. The presence of symptoms was assessed at the time of resection. Imaging data obtained at each clinic visit was reviewed to evaluate mass size and annual growth rate. Catecholamine data were reviewed to evaluate for data above the upper limit of the reference range. Masses that underwent imaging at least 3 months apart were considered in our surveillance cohort. Results Median follow up was 16.7 years. There was a size-dependent increase in catecholamine production (P Conclusion Active surveillance is a safe strategy for management of VHL associated pheochromocytoma in masses less than 2 cm.
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