Effective method for the synthesis of azolo[1,5-a]pyrimidin-7-amines

Condensation of aminoazoles with (2E)-(3-morpholin-4-yl)acrylonitrile and 3,3-diethoxypropionitrile was used to synthesize a series of azolo[1,5-a]pyrimidin-7-amines. It was established that the reactions with certain aminotriazoles gave mixtures of regioisomers: azolo[1,5-а]pyrimidin-7-amines and azolo[4,3-а]pyrimidin-5-amines.