Abstract 19173: Effect of Adjunct Vitamin D Therapy on Vascular Function in African-Americans With Poorly Controlled Hypertension and Hypertensive Heart Disease

Introduction: Vitamin D deficiency has been associated with adverse vascular function including central aortic pressure (CAP), augmentation index (AI) and pulse wave velocity (PWV) in observational studies. Hypothesis: We hypothesized that vitamin D supplementation in African Americans with poorly controlled HTN and hypertensive heart disease would modify these measures of vascular function. Methods: Participants were recruited from a single center, urban emergency department. Those with vitamin D deficiency (< 20 ng/ml) underwent magnetic resonance imaging to measure left ventricular mass index (LVMI). Participants with increased LVMI were randomized to receive evidence based antihypertensive therapy (goal BP < 130/80 mmHg) along with adjunct vitamin D (50,000 IU every other week) or matching placebo for 1 year. Applanation tonometry was repeated at 16 and 52 weeks to measure CAP, PWV and AI. Results: A total of 354 participants were screened, 113 (32%) of whom were randomized. Fifty-five participants we...