G66(P) Reduced rates of juvenile onset recurrent respiratory papillomatosis in australia after implementation of a national hpv vaccination program

Aims Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) is a rare chronic disease caused by human papillomavirus (HPV) types 6 and 11. Children with RRP require multiple surgical interventions. Tracheostomy may be needed and sometimes the disease is fatal. These infections are now preventable through HPV vaccination. Following an extensive quadrivalent HPV vaccine catch-up program for females aged 12–26 years in 2007–2009, in Australia, we aimed to monitor the changes in incidence and demographics of JoRRP over time. Methods The Australian Paediatric Surveillance Unit (APSU) conducted national surveillance for JRRoP using its well established reporting system. In addition to the ~1450 paediatricians who report to the APSU each month, paediatric otorhinolaryngologists were also enrolled in the APSU and offered HPV typing. We report findings for the five-year period to end 2016. Results The average annual incidence rate was 0.0715 per 1 00 000 children aged Conclusion To our knowledge this is the first report internationally documenting decline in JoRRP incidence in children following a quadrivalent HPV vaccination program.