The Framingham cardiovascular risk score in multiple sclerosis (P1.134)

OBJECTIVE. Different cardiovascular risk factors have been related to the risk of developing multiple sclerosis (MS), and to MS disability and course. However, it is possible that such factors interact variably, thus determining a global risk in MS subjects. We aim to compare the global cardiovascular risk of MS subjects with controls, and to evaluate its importance on MS-related disability, progression and treatment. METHODS. In our cross-sectional study design, age, gender, smoking status, body mass index, systolic blood pressure, diabetes, and use of antihypertensive medications have been recorded in MS subjects and controls to calculate the simplified 10-year Framingham General Cardiovascular Disease Risk Score (FR), an individualized percentage risk score estimating the 10-year likelihood of cardiovascular events. RESULTS. We recruited 265 MS subjects and matched 530 controls by propensity score. T-test showed similar FR between MS subjects and controls (p=0.212). Linear regression analysis showed a direct relationship between FR and Expanded Disability Status Scale (p<0.001) and MS Severity Scale (p<0.001). Analysis of variance showed a trend in reduced FR in Natalizumab when compared to Interferon, Fingolimod or no current disease modifying treatment (p=0.057). T-test showed significantly higher FR in secondary progressive MS when compared to relapsing remitting MS (p<0.001). CONCLUSIONS. The FR, evaluating the global cardiovascular health by the interaction among different risk factors, seems to be related to MS disability and progression. Modifiable cardiovascular risk factors should be carefully investigated and corrected with a possible effect on MS-related outcomes. Study Supported by: the present study received no specific support. Disclosure: Dr. Moccia has nothing to disclose. Dr. Lanzillo has nothing to disclose. Dr. Palladino has nothing to disclose. Dr. Maniscalco has nothing to disclose. Dr. De Rosa has nothing to disclose. Dr. Russo has nothing to disclose. Dr. Massarelli has nothing to disclose. Dr. Carotenuto has nothing to disclose. Dr. Postiglione has nothing to disclose. Dr. Caporale has nothing to disclose. Dr. Triassi has nothing to disclose. Dr. Brescia Morra has nothing to disclose.