A Concise Asymmetric Synthesis of the Macrolide Antibiotic (-)-A26771B and Evaluation of its Antibacterial Activity and Some of its Precursors

An asymmetric synthesis of the macrolide antibiotic (-)-A26771B (1) has been developed wherein the stereochemistries at its C-5 and C-15 centres were installed using an (R)-BINOL-catalyzed allylati...