Paraoxonase protection of LDL against peroxidation is independent of its esterase activity towards paraoxon and is unaffected by the Q

High density lipoprotein (HDL)-associated paraox- onase (PON) seems to play a major role in the protection of low density lipoprotein (LDL) against peroxidation by HDL, and the partly purified enzyme exerts a dose-depen- dent protective effect. A common polymorphism of the hu- man gene (192 Q