15-Acetylthioxy-furodysinin lactone, a potent LTB4 receptor partial agonist from a marine sponge of the genus Dysidea

Abstract A novel sesquiterpene thioacetate with high binding-affinity for the human leukotriene B 4 (LTB 4 ) receptor has been isolated from the sponge Dysidea sp. collected in Palau. The structure of the new compound was determined on the basis of spectral data and the compound was prepared semi-synthetically by photo-oxidation of the known metabolite, thiofurodysin acetate.