Polymorphisms of the human OGG1 gene in laryngeal cancer: implications in radiotherapy response and survival.

UNLABELLED: The human OGG1 (hOGG1) gene encodes a DNA glycosylase involved in the excision repair of 8-hydroxy-2'-deoxyguanine (8-OH-dG) from oxidatively-damaged DNA. Ser326Cys polymorphism in the hOGG1 gene is involved in the repair of 8-hydroxyguanine in oxidatively damaged DNA, and appears to be related to susceptibility to certain smoking and alcohol-related orolaryngeal cancers. OBJECTIVE: To analyse if hOGG1 Ser326Cys (exon 7: m6) polymorphism is associated with tumour localization, T, stage and histologic differentiation, and if radiotherapy results were influenced by this polymorphism. MATERIAL AND METHOD: Blood samples were obtained before treatment from seventy one patients with laryngeal cancer and screened by a PCR-RFLP method. RESULTS: Although hOGG1 gene is important in DNA repair mechanisms, no significant association was observed between hOGG1 Ser326Cys (exon 7: m6) polymorphism, tumour characteristics and radiotherapy results. CONCLUSION: So the analysis of this polymorphism is not important for treatment decision in laryngeal cancer patients.