Research status and progress of Glypican-3 and liver carcinoma

Phosphatidylinositol protein 3 (Glypican-3, GPC3) is a cell-surface heparan sulfate proteoglycan that belongs to the glycine related global membrane proteoglycan relatives.Many studies have shown that it is of great significance in the occurrence, diagnosis, treatment and prognosis of hepatocellular carcinoma (HCC).This paper reviews the recent studies on GPC3. Key words: Liver neoplasms; Glypicans; Biomarkers, tumor; Prognosis