Physicochemical parameters of perfluorocarbon emulsions with different osmolarities

The physicochemical properties of emulsions based on perfluorocarbons (PFC) and phospholipids (PL) with osmolarities from ~80 to ~230 mOsm were studied in conditions of normal storage at +4°C and in “accelerated aging” storage at +37°C. Heat sterilization of emulsions with osmolarities of ~80 mOsm had no effect on particle size or structure. The pH and structure of these media remained unchanged for 12 months of normal storage. Increases in the osmolarity to ~230 mOsm had no effect on the stability of the emulsions: particle size and structure and pH and viscosity remained unaltered for 30 - 40 days of “accelerated aging” or for a year in normal (+4°C) conditions.