Renal vasodilators and hypertension

SK&F 82526 is a potent renal vasodilator in dogs, monkeys, and hypertensive rats. It is orally active and has a specificity for the renal vasculature greater than dopamine. Its activity is owing, at least in part, to stimulation of renal dopamine receptors and has no effect on α- or β-adrenergic receptors. This compound should be valuable in further examining the importance of renal blood flow in essential hypertension.