HISTIOCYTOSIS OF LANGERHANS CELLS IN A NEWBORN: A CASE REPORT
2020
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplastic proliferation with variable clinical behavior; the male:female ratio is 1.6:1.0. The pathogenesis of LCH is imperfectly understood. A newborn boy, 1 month old, had a small focal lesion with a papillomatous surface, was cured, and the tissue removed was granulomatous, friable, and bleeding. The microscopic examination revealed histiocytes with abundant eosinophilic cytoplasm and lobulated or coffee bean-like nucleus admixed with a variable number of eosinophils, lymphocytes, and neutrophils. In a immunohistochemical study, cells were positive for CD1A, S100, CD68, and fascin. The patient was referred to the onco-hematology service of a pediatric hospital and had his body fully examined, without other lesions being identified. After a 2-year follow-up, there was no recurrence. At the site where the lesion was cured, an ulcer remained, through which the early eruption of the tooth 84 occurred. This tooth is currently present.
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