RELATIVE INHIBITION INDEX OF ANTIFUNGAL DRUGS BY DIFFUSION AGAR SUSCEPTIBILITY TEST

The diffusion agar susceptibility test for the antifungal drugs has not been validated yet. The aim of this work has been the analysis of the dose-response line, the relative diffusion rate and the residual activity concerning inhibition zone formation in home-made medium for amphotericin B, 5-flucytosine, fluconazole and itraconazole. Furthermore, the Relative Inhibition Index was calculated. With our methods it is possible to better discriminate the results of "in vitro" antifungal activity above all with those which are less diffused in agar medium.