General problems with clinical trials in research

Evidence-based medicine (EBM) has as its aim and concern the identification and evaluation of the entire body of published evidence concerning a medical problem with a view to making the results available, assessable and easily usable in medical practice. It therefore sees itself first and foremost as an instrument of medical decision-making with the task of supporting physicians in their day-to-day work with patients. EBM’s central stipulation is the provision of external evidence in the form of scientifically verified knowledge.