Wpływ polimorfizmów genów ACE i angiotensynogenu na rozwój otyłości brzusznej oraz strukturę i funkcję mięśnia lewej komory — wyniki 10-letniej prospektywnej obserwacji młodych zdrowych mężczyzn
2011
Background Genetic and environmental factors play a major
role in the pathogenesis of hypertension. The aim of
this study was to investigate whether the insertion/deletion
(I/D) polymorphism of angiotensin-converting enzyme
(ACE) gene and angiotensinogen (AGT) gene increase
the susceptibility to abdominal obesity and affect left ventricular
function and structure in a 10-year follow-up of
a young healthy male population
Material and methods The study was carried out in
a group of 68 normotensive subjects, aged 23 ± 3.5 years,
mean ± SD. The subjects underwent the following procedures:
anthropometric measurements, basic biochemical
tests, office blood pressure measurements, ambulatory
blood pressure measurements (ABPM), echocardiography.
The I/D polymorphism within intron 16
of the ACE gene and AGT gene polymorphism (the allele
M235T and T174M) were genotyped by polymerase
chain reaction.
Results No relationship between waist circumference
and ACE, AGT polymorphisms was observed. The
structural changes of the heart differed significantly in
T174M AGT TT genotype with increased septum/
/posterior wall ratio compared to TM and MM: (1.20 ±
0.12 v. 1.1 ± 0.11 cm; p Conclusions In a healthy population, the ACE and AGT
polymorphisms might contribute to the structural and
functional changes of the heart, but not to development of
abdominal obesity or hypertension.
Arterial Hypertension 2011, vol. 15, no 4, pages 242–250.
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